Push Dose Epinephrine

Mixing:

  • Empty 1 cc from a 10 cc flush
  • Draw up 1 cc from code cart epinephrine (1 amp, 100mcg/ml) and add it to the saline syringe
  • Shake. Label syringe. Now each 1 ml contains 10 mcg of epinephrine

Dose:

  • 0.5-2 ml (5-20 micrograms) every 2-5 minutes PRN hypotension
  • Typical duration is 5-10 minutes 
  • Onset <1 min

Pharmacology

Alpha and Beta (1/2) agonist. Increases blood pressure and heart rate. 

Further Reading

Updates and Controversies in the Early Management of Sepsis and Septic Shock (Pharmacology CME) Date Release: Apr 2021 Sepsis and septic shock guidelines, requirements, criteria, and treatments have changed substantially in the last few years. This issue reviews the latest evidence and discusses the changes and current controversies in sepsis diagnosis and management.

Calcium Channel Blocker and Beta Blocker Overdose, and Digoxin Toxicity Management – Pharmacology EXTRA Supplement (Pharmacology CME) Date Release: Sep 2020 This Pharmacology EXTRA CME supplement (free to Emergency Medicine Practice subscribers) provides an evidence-based overview of emergency department management of calcium-channel blocker overdose, beta blocker overdose, and digoxin toxicity, and focuses on the caveats of treatment for each.

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