Take a deeper dive into our peer-reviewed emergency medicine content with the EMplify podcast. Join hosts Sam Ashoo, MD and T.R. Eckler, MD for educational, conversational reviews of current evidence guaranteed to help you make your best clinical decisions. Each high-yield episode gives you practical, time-tested guidance from practicing emergency medicine clinicians and subject-matter experts. Listen and learn!
In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the September 2026 Emergency Medicine Practice article, Emergency Department Diagnosis and Management of Acetaminophen or Salicylate Toxicity
1:13 — Welcome and topic introduction
3:50 — Key rules: check levels, call Poison Control
5:13 — Acetaminophen pathophysiology
8:16 — Salicylate pathophysiology
10:51 — Coingestions
11:11 — Differential diagnosis
12:19 — History & pre-hospital care
15:28 — Product confusion
17:08 — Toxic dose thresholds
18:26 — Physical exam & vital signs
20:16 — Acetaminophen toxicity stages (1-4)
22:35 — Salicylate exam findings
23:43 — Lab workup & testing
24:45 — Acetaminophen nomogram & levels
30:39 — Activated charcoal — when to give it
34:11 — NAC therapy — dosing & timing
37:22 — Hemodialysis for acetaminophen
38:40 — King’s College Criteria
41:00 — Salicylate treatment
44:42 — Potassium management during alkalinization
47:28 — Hemodialysis for salicylate
48:05 — Intubation
50:00 — Pregnancy considerations
51:20 — Pediatric considerations
52:06 — Emerging: fomepizole as adjunct therapy
52:45 — Summary & wrap-up
Subscribers, take the CME test here.
Emergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net
In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the September 2026 Emergency Medicine Practice article, Emergency Department Diagnosis and Management of Acetaminophen or Salicylate Toxicity
- 1:13 — Welcome and topic introduction
- 3:50 — Key rules: check levels, call Poison Control
- 5:13 — Acetaminophen pathophysiology
- 8:16 — Salicylate pathophysiology
- 10:51 — Coingestions
- 11:11 — Differential diagnosis
- 12:19 — History & pre-hospital care
- 15:28 — Product confusion
- 17:08 — Toxic dose thresholds
- 18:26 — Physical exam & vital signs
- 20:16 — Acetaminophen toxicity stages (1-4)
- 22:35 — Salicylate exam findings
- 23:43 — Lab workup & testing
- 24:45 — Acetaminophen nomogram & levels
- 30:39 — Activated charcoal — when to give it
- 34:11 — NAC therapy — dosing & timing
- 37:22 — Hemodialysis for acetaminophen
- 38:40 — King’s College Criteria
- 41:00 — Salicylate treatment
- 44:42 — Potassium management during alkalinization
- 47:28 — Hemodialysis for salicylate
- 48:05 — Intubation
- 50:00 — Pregnancy considerations
- 51:20 — Pediatric considerations
- 52:06 — Emerging: fomepizole as adjunct therapy
- 52:45 — Summary & wrap-up
Subscribers, take the CME test here.
Emergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net
Sam Ashoo, MD, FACEP, is board certified in emergency medicine and clinical informatics. He serves as EB Medicine’s editor-in-chief of interactive clinical pathways and FOAMEd blog, and host of EB Medicine’s EMplify podcast. Follow him below for more…
