Take a deeper dive into our peer-reviewed emergency medicine content with the EMplify podcast. Join hosts Sam Ashoo, MD and T.R. Eckler, MD for educational, conversational reviews of current evidence guaranteed to help you make your best clinical decisions. Each high-yield episode gives you practical, time-tested guidance from practicing emergency medicine clinicians and subject-matter experts. Listen and learn!
In this episode, Sam Ashoo, MD and T.R. Eckler, MD discuss the Januray 2026 Emergency Medicine Practice article, Emergency Department Diagnosis and Management of Patients With Syphilis
Syphilis cases have surged 42% in the US, making it critical for emergency physicians to recognize and treat this “great masquerader.” In this episode, hosts Sam Ashoo and Dr. T.R. Eckler break down the January 2026 Emergency Medicine Practice article on syphilis diagnosis and management. They cover the rising prevalence in high-risk populations, the four clinical stages (primary, secondary, latent, and tertiary), special presentations like neurosyphilis and congenital syphilis, and practical diagnostic approaches. With a national penicillin shortage, they discuss alternative treatment options including doxycycline and post-exposure prophylaxis. The conversation also addresses the dark history of the Tuskegee Study and its lasting impact on medical ethics. Whether you’re seeing more cases in your ED or want to sharpen your diagnostic skills, this episode provides actionable insights for frontline providers.
Timestamps
[0:00] Opening/Introduction
[0:11] Host Welcome & Resources
[0:50] Episode Introduction
[1:30] Epidemiology & Rising Cases
[4:30] Risk Factors & Screening
[6:30] Pathophysiology & Transmission
[9:30] Primary Syphilis
[12:30] Secondary Syphilis
[15:30] Tertiary & Latent Syphilis
[18:30] Neurosyphilis
[22:30] Congenital Syphilis
[25:30] Ocular & Otic Syphilis
[28:30] Differential Diagnosis & Pre-hospital Care
[31:30] History & Physical Examination
[34:30] Diagnostic Testing Overview
[38:30] Testing Details & Titers
[41:30] Treatment: Penicillin & Alternatives
[43:30] Closing
Subscribers, take the CME test here.
Emergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net
In this episode, Sam Ashoo, MD and T.R. Eckler, MD discuss the Januray 2026 Emergency Medicine Practice article, Emergency Department Diagnosis and Management of Patients With Syphilis
Syphilis cases have surged 42% in the US, making it critical for emergency physicians to recognize and treat this “great masquerader.” In this episode, hosts Sam Ashoo and Dr. T.R. Eckler break down the January 2026 Emergency Medicine Practice article on syphilis diagnosis and management. They cover the rising prevalence in high-risk populations, the four clinical stages (primary, secondary, latent, and tertiary), special presentations like neurosyphilis and congenital syphilis, and practical diagnostic approaches. With a national penicillin shortage, they discuss alternative treatment options including doxycycline and post-exposure prophylaxis. The conversation also addresses the dark history of the Tuskegee Study and its lasting impact on medical ethics. Whether you’re seeing more cases in your ED or want to sharpen your diagnostic skills, this episode provides actionable insights for frontline providers.
Timestamps
[0:00] Opening/Introduction
[0:11] Host Welcome & Resources
[0:50] Episode Introduction
[1:30] Epidemiology & Rising Cases
[4:30] Risk Factors & Screening
[6:30] Pathophysiology & Transmission
[9:30] Primary Syphilis
[12:30] Secondary Syphilis
[15:30] Tertiary & Latent Syphilis
[18:30] Neurosyphilis
[22:30] Congenital Syphilis
[25:30] Ocular & Otic Syphilis
[28:30] Differential Diagnosis & Pre-hospital Care
[31:30] History & Physical Examination
[34:30] Diagnostic Testing Overview
[38:30] Testing Details & Titers
[41:30] Treatment: Penicillin & Alternatives
[43:30] Closing
👉 Subscribers, take the CME test here.
✨ Emergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net
Last Updated on February 3, 2026
Sam Ashoo, MD, FACEP, is board certified in emergency medicine and clinical informatics. He serves as EB Medicine’s editor-in-chief of interactive clinical pathways and FOAMEd blog, and host of EB Medicine’s EMplify podcast. Follow him below for more…
