Take a deeper dive into our peer-reviewed emergency medicine content with the EMplify podcast. Join hosts Sam Ashoo, MD and T.R. Eckler, MD for educational, conversational reviews of current evidence guaranteed to help you make your best clinical decisions. Each high-yield episode gives you practical, time-tested guidance from practicing emergency medicine clinicians and subject-matter experts. Listen and learn!
In this episode, Sam Ashoo, MD and Dr. Dana Klavansky, MD discuss the March 2026 Emergency Medicine Practice article, Emergency Department Evaluation and Management of Severe Traumatic Brain Injury
- Introduction & Welcome (0:15)
- Guest Introduction (0:55)
- Epidemiology of Severe TBI (2:37)
- Pathophysiology: Primary vs. Secondary TBI (4:24)
- Types of Hemorrhage and Hematomas (5:25)
- Classification (7:31)
- Mild vs. Moderate vs. Severe TBI
- Impact Loading vs. Inertial Loading
- Differential Diagnosis (9:22)
- Prehospital Care (9:42)
- Emergency Department History (13:33)
- Diagnostics (15:13)
- CT Scan and the A-B-B-B-C Approach
- Repeat CT Timing
- Bedside Ultrasound for Optic Nerve Sheath Diameter
- Pupillometry
- Biomarkers
- Treatment (24:52)
- Airway Management
- Ventilation and CO2 Targets
- Hyperosmolar Therapy: Hypertonic Saline and Mannitol
- Cerebral Perfusion Pressure
- Blood Pressure Goals
- Temperature Management
- Coagulopathy Management
- Seizure Prophylaxis and EEG Monitoring
- Tiered ICP Management (35:29)
- Surgical Indications (38:40)
- Prognosis (40:33)
- Special Topics (41:30)
- Sports Injuries and CTE
- Tranexamic Acid (CRASH-3 Trial)
- Wrap-Up (43:46)
Subscribers, take the CME test here.
Emergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net

In this episode, Sam Ashoo, MD and Dr. Dana Klavansky, MD discuss the March 2026 Emergency Medicine Practice article, Emergency Department Evaluation and Management of Severe Traumatic Brain Injury
- Introduction & Welcome (0:15)
- Guest Introduction (0:55)
- Epidemiology of Severe TBI (2:37)
- Pathophysiology: Primary vs. Secondary TBI (4:24)
- Types of Hemorrhage and Hematomas (5:25)
- Classification (7:31)
- Mild vs. Moderate vs. Severe TBI
- Impact Loading vs. Inertial Loading
- Differential Diagnosis (9:22)
- Prehospital Care (9:42)
- Emergency Department History (13:33)
- Diagnostics (15:13)
- CT Scan and the A-B-B-B-C Approach
- Repeat CT Timing
- Bedside Ultrasound for Optic Nerve Sheath Diameter
- Pupillometry
- Biomarkers
- Treatment (24:52)
- Airway Management
- Ventilation and CO2 Targets
- Hyperosmolar Therapy: Hypertonic Saline and Mannitol
- Cerebral Perfusion Pressure
- Blood Pressure Goals
- Temperature Management
- Coagulopathy Management
- Seizure Prophylaxis and EEG Monitoring
- Tiered ICP Management (35:29)
- Surgical Indications (38:40)
- Prognosis (40:33)
- Special Topics (41:30)
- Sports Injuries and CTE
- Tranexamic Acid (CRASH-3 Trial)
- Wrap-Up (43:46)
Subscribers, take the CME test here.
Emergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net

Sam Ashoo, MD, FACEP, is board certified in emergency medicine and clinical informatics. He serves as EB Medicine’s editor-in-chief of interactive clinical pathways and FOAMEd blog, and host of EB Medicine’s EMplify podcast. Follow him below for more…

