
A 21-year-old transgender man presents to urgent care with 2 days of dysuria, urinary frequency, and suprapubic discomfort. His chart lists male gender, and the medical assistant initially documents “male patient with possible prostatitis.” His vital signs are temperature, 98.8°F; heart rate, 88 beats/min; blood pressure, 118/72 mm Hg; respiratory rate, 14 breaths/min; and oxygen saturation, 100% on room air. He appears comfortable and nontoxic. Examination reveals mild suprapubic tenderness without guarding or rebound; there is no costovertebral angle tenderness. During a private, anatomy-based history, the patient shares that he has a vagina and uterus, has not had genital surgery, and recently had receptive vaginal sex with a new partner. He is taking testosterone but is not using contraception. Urinalysis shows leukocyte esterase and nitrites.
Which of the following is the most appropriate next step?
- Treat for prostatitis because the patient’s chart lists male gender.
- Avoid asking about anatomy or sexual practices because these questions may be intrusive.
- Treat for uncomplicated urinary tract infection and consider pregnancy and STI testing based on anatomy and exposure.
- Refer the patient to the emergency department because all genitourinary symptoms in TGD patients require higher-level care.
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Correct answer: c. Treat for uncomplicated urinary tract infection when appropriate and consider pregnancy and STI testing based on anatomy and exposure.
Rationale: TGD patients may have anatomy that differs from assumptions based on appearance or the electronic health record. A focused organ inventory and sexual history can prevent missed diagnoses and guide appropriate testing, including pregnancy and STI testing when clinically relevant. Testosterone should not be considered contraception.
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Tracey Davidoff, MD, FACP, FCUCM, has practiced Urgent Care Medicine for more than 15 years. She is Board Certified in Internal Medicine. Dr. Davidoff is a member of the Board of Directors of the Urgent Care Association and serves as Co-Editor-in-Chief of the College of Urgent Care Medicine’s “Urgent Caring” publication. She is also the Vice President of the Southeast Regional Urgent Care Association and a member of the editorial board of the Journal of Urgent Care Medicine. At EB Medicine, Dr Davidoff is Editor-In-Chief of Evidence-Based Urgent Care, and co-host of the Urgentology podcast.

