Take a deeper dive into our peer-reviewed emergency medicine content with the EMplify podcast. Join hosts Sam Ashoo, MD and T.R. Eckler, MD for educational, conversational reviews of current evidence guaranteed to help you make your best clinical decisions. Each high-yield episode gives you practical, time-tested guidance from practicing emergency medicine clinicians and subject-matter experts. Listen and learn!
In this episode, Sam Ashoo, MD and Dr. Syeda Maria Muzammil, MD discuss the August 2026 Emergency Medicine Practice article, Emergency Department Management of Postthrombolysis Intracranial Hemorrhage.
- 0:25 – Intro & sponsor message
- 1:18 – Guest introduction: Dr. Maria Muzammil
- 2:24 – Timeframe for post-thrombolysis hemorrhage & ED/ICU boarding considerations
- 4:46 – Thrombolysis eligibility criteria & contraindications
- 5:46 – Incidence rates & symptomatic vs. asymptomatic hemorrhage
- 7:09 – Pathophysiology & risk factors for post-thrombolytic ICH
- 10:18 – Combining IV thrombolysis with endovascular thrombectomy
- 12:33 – Post-treatment monitoring protocols & neurological exam frequency
- 15:02 – Differentiating hemorrhage from other causes of neurological decline
- 18:34 – Initial ED steps
- 20:35 – Heidelberg classification of hemorrhage types
- 21:60 – Follow-up imaging
- 25:27 – Treatment of confirmed hemorrhage
- 30:10 – Platelet transfusion guidance
- 32:39 – Delayed hemorrhage & treatment timing considerations
- 34:21 – Blood pressure management goals post-hemorrhage
- 37:20 – Special populations
- 38:48 – Summary of ED management algorithm
- 40:48 – Closing remarks
Subscribers, take the CME test here.
Emergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net

In this episode, Sam Ashoo, MD and Dr. Syeda Maria Muzammil, MD discuss the August 2026 Emergency Medicine Practice article, Emergency Department Management of Postthrombolysis Intracranial Hemorrhage.
- 0:25 – Intro & sponsor message
- 1:18 – Guest introduction: Dr. Maria Muzammil
- 2:24 – Timeframe for post-thrombolysis hemorrhage & ED/ICU boarding considerations
- 4:46 – Thrombolysis eligibility criteria & contraindications
- 5:46 – Incidence rates & symptomatic vs. asymptomatic hemorrhage
- 7:09 – Pathophysiology & risk factors for post-thrombolytic ICH
- 10:18 – Combining IV thrombolysis with endovascular thrombectomy
- 12:33 – Post-treatment monitoring protocols & neurological exam frequency
- 15:02 – Differentiating hemorrhage from other causes of neurological decline
- 18:34 – Initial ED steps
- 20:35 – Heidelberg classification of hemorrhage types
- 21:60 – Follow-up imaging
- 25:27 – Treatment of confirmed hemorrhage
- 30:10 – Platelet transfusion guidance
- 32:39 – Delayed hemorrhage & treatment timing considerations
- 34:21 – Blood pressure management goals post-hemorrhage
- 37:20 – Special populations
- 38:48 – Summary of ED management algorithm
- 40:48 – Closing remarks
Subscribers, take the CME test here.
Emergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net

Sam Ashoo, MD, FACEP, is board certified in emergency medicine and clinical informatics. He serves as EB Medicine’s editor-in-chief of interactive clinical pathways and FOAMEd blog, and host of EB Medicine’s EMplify podcast. Follow him below for more…

